Wysa Clinical Evidence & Research | Everyday Mental Health

Wysa has a strong base of clinical evidence in behavioral health, with peer-reviewed trials and efficacy studies across a range of clinical concerns, geographies and age groups.

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Research Partners
Wysa Receives FDA Breakthrough Device Designation for AI-led Mental Health Conversational Agent

The FDA Breakthrough Device Designation follows an independent peer-reviewed clinical trial, published in JMIR, that found Wysa to be effective in the management of chronic pain, and associated depression and anxiety. The device was found to be more effective than standard orthopedic care, and comparable to in-person psychological counseling.

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Research at Wysa
Our behavioural health evidence consists of independent clinical trials that have sought to examine the solution with scientific rigor, and through the lens of real-world implementation. The studies are strongly guided by the voice of the user through co-design and qualitative methodologies, and document our work across clinical concerns of depression, anxiety, pain and chronic conditions.

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Clinical Trials
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Service Evaluations
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Real-World Studies
Peer-Reviewed Research

Wysa has more than 36 peer-reviewed publications in partnership with academic institutions such as Cambridge University, Harvard University and Washington University of St. Louis amongst others, demonstrating the efficacy of Wysa across multiple clinical concerns. Contact us for the entire list of our publications.
Effectiveness of a Mental Health Chatbot for People With Chronic Diseases: Randomized Controlled Trial
Understanding Digital Mental Health Needs and Usage with an AI-led Mental Health App (Wysa) during the COVID-19 Pandemic: Retrospective Analysis
A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study
Multi-stakeholder perspectives regarding preferred modalities for mental health intervention delivered in the orthopedic clinic: a qualitative analysis
Perceptions of a Digital Mental Health Platform Among Participants With Depressive Disorder, Anxiety Disorder, and Other Clinically Diagnosed Mental Disorders in Singapore: Usability and Acceptability Study
Language Adaptations of Mental Health Interventions: User Interaction Comparisons with an AI-enabled Conversational Agent (Wysa) in English and Spanish
Understanding the impact of an AI-enabled Conversational Agent (Wysa) on users with a self-reported maternal event: A mixed method real-world data study
Adherence and Engagement With a Cognitive Behavioral Therapy-Based Conversational Agent (Wysa for Chronic Pain) Among Adults With Chronic Pain: Survival Analysis
Evaluating User Feedback for an Artificial Intelligence-Enabled, Cognitive Behavioral Therapy-Based Mental Health App (Wysa): Qualitative Thematic Analysis
An Empathy-Driven, Conversational Artificial Intelligence Agent (Wysa) for Digital Mental Well-Being: Real-World Data Evaluation Mixed-Methods Study
Understanding People With Chronic Pain Who Use a Cognitive Behavioral Therapy–Based Artificial Intelligence Mental Health App (Wysa): Mixed Methods Retrospective Observational Study
Evaluating the Therapeutic Alliance With a Free-Text CBT Conversational Agent (Wysa): A Mixed-Methods Study
A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study
Partner with Wysa for Research

We aim to support the innovation and evidence-building within digital mental health and are always looking to connect with researchers.

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One of our first studies was a real-world mixed methods study on the effectiveness and engagement of Wysa on anonymous global users.

Watch Dr. Becky Inkster talk about the research study published in JMIR mHealth & uHealth.

Read the study

Research Partners

Wysa Receives FDA Breakthrough Device Designation for AI-led Mental Health Conversational Agent

Research at Wysa

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Peer-Reviewed Research

One of our first studies was a real-world mixed methods study on the effectiveness and engagement of Wysa on anonymous global users. Watch Dr. Becky Inkster talk about the research study published in JMIR mHealth & uHealth.

One of our first studies was a real-world mixed methods study on the effectiveness and engagement of Wysa on anonymous global users.

Watch Dr. Becky Inkster talk about the research study published in JMIR mHealth & uHealth.